You can opt out at any time or find out more by reading our cookie policy. In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products. To email a medicine you must sign up and log in. Cyclizine given intravenously, in half the recommended dose, increases the lower oesophageal sphincter tone and thereby reduces the hazard of regurgitation and aspiration of gastric contents if given to patients, undergoing emergency surgery, before induction of general anaesthesia. Hypersensitivity reactions, including anaphylaxis have occurred. Central nervous system effects include drowsiness, dizziness, incoordination, ataxia, weakness, hyperexcitability, disorientation, impaired judgement, hallucinations, hyperkinesia, extrapyramidal motor disturbances, convulsions, hyperpyrexia and respiratory depression.

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Elderly There have been no specific studies of Valoid in the elderly.

Hepatobiliary disorders Not known Hepatic dysfunction see section 4. System Organ Class Frequency Adverse reactions Blood and lymphatic system disorders Not syrinye Agranulocytosis, leucopenia, haemolytic anaemia, thrombocytopenia. Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.

Valoid is indicated in adults for the cycilzine and treatment of nausea and vomiting cylcizine Younger children are more susceptible to convulsions. Cyclizine may counteract the haemodynamic benefits of opioid analgesics.

By rectum For Child 2—5 years Abdominal pain ; agranulocytosis ; angioedema ; anxiety ; apnoea ; appetite decreased ; arrhythmias ; asthenia ; bronchospasm ; constipation ; diarrhoea ; disorientation ; dizziness ; drowsiness ; dry mouth ; dry throat ; euphoric mood ; haemolytic vyclizine ; hallucinations ; headache ; hepatic disorders ; hypertension ; hypotension ; increased gastric reflux ; insomnia ; leucopenia ; movement disorders ; muscle complaints ; nasal dryness ; nausea ; oculogyric crisis ; palpitations ; paraesthesia ; photosensitivity reaction ; seizure ; skin reactions ; speech disorder ; thrombocytopenia ; tinnitus ; tremor ; urinary retention ; vision blurred ; vomiting.


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Agranulocytosis, leucopenia, haemolytic anaemia, thrombocytopenia. This medicinal product is indicated in adults for the prevention and treatment of nausea and vomiting including: Thus intravenous cyclizine, should be used with caution in all patients and with particular care in patients with underlying neuromuscular disorders.

Breastfeeding Cyclizine is excreted in human milk, however, the amount has not been quantified. Further reading and references. In the management of acute overdosage with Valoid, gastric lavage and supportive measures for respiration and circulation should be performed if necessary.

Cyclizine Lactate 50 mg/ml Solution for Injection

To view the changes to a medicine you must sign up and log in. Palliative care for adults: Vomiting due to doe stasis or compression. It does not produce more effective analgesia than the oral route unless the patient cannot use oral medication, or has serious compliance problems.

For storage conditions after dilution of the medicinal product, see section 6.

Cyclizine Lactate 50 mg/ml Injection – Summary of Product Characteristics (SmPC) – (eMC)

cyclizune A sensation of heaviness, chills and pruritus have been reported rarely. Inability to take medication orally. Cyclizine is a histamine H 1 receptor antagonist of the piperazine class which is characterised by a low incidence of drowsiness. Sign Up Log In Cancel. Cyclizine increases lower oesophageal sphincter tone and reduces the sensitivity of the labyrinthine apparatus. Other common indications for using a syringe driver in palliative care include the treatment of nausea and vomiting, excessive respiratory secretions, and agitation or restlessness.


Syringe Drivers

May cause drowsiness and anticholinergic side-effects. Hepatic rose see section 4. Company contact details hameln pharmaceuticals ltd. Symptoms Symptoms of acute toxicity from cyclizine arise from peripheral anticholinergic effects and effects on the central nervous system.

Gastrointestinal disorders Dryness of the mouth, nose and throat, constipation, increased gastric reflux, nausea, vomiting, diarrhoea, stomach pain, loss of appetite. Sublingual administration is not always easy if the mouth is dry, co-ordination is poor or cognitive cycizine is impaired. Mutagenicity Cyclizine was not mutagenic in a full Ames test, including use of S9-microsomes but can nitrosate in vitro to form mutagenic products.

Because of its anticholinergic activity, cyclizine may enhance the side-effects of other anticholinergic drugs, and may have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants both tricyclics and MAOIs.